2018Äê10ÔÂ15ÈÕ£¬1xbetÍøÒ³°æÊ¯Ñå¿ÎÌâ×éÔÚ¡¶Nature Communications¡·ÔÚÏß·¢±íÌâΪ¡°A phosphatidylinositol 4,5-bisphosphate redistribution-based sensing mechanism initiates a phagocytosis programing¡±µÄÑо¿ÂÛÎÄ£¬±¨µÀÁËϸ°ûĤPIP2·Ö×Ӻ͹ǼÜÏà¹Øµ°°×MoesinÔÚ·ÇÉúÎïÐÔ¹ÌÌå¿ÅÁ£µÄÍÌÊÉ×÷ÓÃÖеÄ×÷ÓúÍÏà¹Ø»úÖÆ£¬²¢³õ²½Ì½Ë÷ÁËÕâÒ»±£ÊصÄÐźÅϵͳÔÚϵͳÑÝ»¯·½ÃæµÄµØÎ»ºÍÒâÒå¡£
ÒÀÀµÊÜÌå-ÅäÌåÏ໥×÷Óô¥·¢µÄÍÌÊÉ×÷Óã¬ÊÇÒ»ÖÖÔڸߵÈÉúÎïÃâÒßϵͳÖвųöÏÖµÄÉúÎïѧÏÖÏó£»¶ø¶ÔÓÚ±íÃæ²¢²»º¬ÓÐÉúÎïÐÔÅäÌåµÄ¹ÌÌå¿ÅÁ££¬ÔòÊÇÔçÆÚÕæºËÉúÎ20ÒÚÄêǰ£©¾Í¾ßÓеÄÒ»ÖÖ¹ÅÀϹ¦ÄÜ£¬Ô¶ÔÚÍÌÊÉÊÜÌå³öÏÖ֮ǰ¾ÍÒѾ´æÔÚ¡£Õë¶ÔÕâЩ¹ÌÌå¿ÅÁ£ÒýÆðµÄÍÌÊÉ×÷Ó㬿ÎÌâ×éÔçÆÚÑо¿½á¹ûÏÔʾ£¬¹ÌÌåÓëϸ°ûĤµÄ½Ó´¥Äܹ»´¥·¢Ï¸°ûĤÖе¨¹Ì´¼µÈÖ¬ÖÊ·Ö×ÓµÄÖØÐÂÅÅÁжøÓÕµ¼ÍÌÊÉ¡£ÕâÒ»ÀàÐ͵ÄÍÌÊÉ×÷ÓÃҲͬÑùÒÀÀµSrc¼Ò×å¡¢SykºÍPI3KµÈϸ°ûÄÚÐźÅͨ·£¬ÓëFcÊÜÌåÒÀÀµµÄÍÌÊÉ×÷ÓÃÊ®·ÖÏàËÆ¡£Õâ¾Í²úÉúÁËÒ»¸ö΢ÃîµÄÎÊÌ⣺ÕâЩ½ø»¯Ñ§ÉÏÍíÆÚ³öÏֵķÖ×ÓÐźÅÔõô»á±»Ô¶¹ÅµÄÍÌÊÉ»úÖÆÀûÓõÄÄØ£¿»»¶øÑÔÖ®£¬Ï¸°ûĤÉÏÖ¬ÖÊ·Ö×ÓÖØÅÅÒý·¢ÏÂÓÎÐźÅͨ·¼¤»îµÄÏêϸ»úÖÆÉв»Çå³þ¡£
¸ÃÏîÑо¿µÄ»ù±¾Âß¼ÈçÏ£¬ÒòΪSykÉÏĤÊÇÉÏÊöÁ½À಻ͬÍÌÊɹ¦ÄܵĹ²Í¬ÒªÇó£¬ÄÇôϸ°ûĤÔÚÍâ½ç¹Ì̬¿ÅÁ£×÷ÓÃϵÄÖ¬ÖÊÖØ×éÓ¦¸ÃÐèҪͨ¹ýÒ»¸öÀàËÆITAMÕâÑùµÄ½á¹¹»ùÐòÀ´²úÉúÏÂÓÎÓ°Ïì¡£¿ÎÌâ×éÔÚСÊó»ùÒò×éÖÐÕÒµ½ÁË1086¸öº¬ÓÐITAMÐòÁеĵ°°×ÖÊ·Ö×Ó£¬Í¨¹ý¶Ô±È£¬É¸Ñ¡£¬ÇóýµÈ·½·¨£¬×îÖÕ·¢ÏÖÒ»ÖÖº¬ÓÐITAMÐòÁеġ¢±£ÊصÄϸ°û¹Ç¼ÜÏà¹Øµ°°×Moesin ¶ÔÖ¬ÖÊÖØ×éµÄÍÌÊɹ¦Äܷdz£ÖØÒª¡£½øÒ»²½µÄ»úÖÆÑо¿½á¹û·Ö±ðÏÔʾ£ºµ±Ò»¸ö·ÇÉúÎïÐÔ¹ÌÌå¿ÅÁ£½Ó´¥µ½Ï¸°ûĤ±íÃæÊ±£¬Äܹ»µ¼ÖÂĤÄÚ²àµÄPIP2·Ö×ÓÔÚ½Ó´¥Ã渽½ü·¢Éú»ý¾Û£¬¶øPIP2·Ö×ÓµÄÕâÒ»ÏìÓ¦ÊÇ×Ô·¢µÄ¡£¼´Ê¹ÔÚÎÞÉúÃüÏÖÏóµÄÄÒÅÝÖУ¬PIP2µÄÕâÖÖ¾Û¼¯Ò²»á·¢Éú¡£Ä¤ÉÏPIP2µÄ¾Û¼¯ÓÖ½øÒ»²½Ä¼¼¯ÁËMoesinµ°°×£¬ Moesinµ°°×µÄFERM½á¹¹ÓòÖÐËùº¬µÄITAMÐòÁÐÄܹ»ÕÐļSyk£¬²¢¼¤»îÆäÏÂÓÎÐźš£

ͼ1. ÊÜÌå½éµ¼ºÍ PIP2-Moesin ½éµ¼µÄÍÌÊÉÐźÅͨ·ģʽͼ
ÒÔITAMΪ´ú±íµÄimmune tyrosineÐźÅÖ»ÔÚÃâÒßϸ°ûÖдæÔÚ£¬ÕâÖÖÌØÊâÐÔһֱûÓÐÒýÆð¹Ø×¢£¬È»¶øËüËÆºõÔÚ°µÊ¾ÃâÒß¹¦ÄܵÄÒ»¸ö¹²Í¬ÆðÔ´¡£ ΪÁË̽¾¿PIP2-MoesinÐźÅͨ·¿ÉÄܵÄÑÝ»¯ÆðÔ´£¬¸ÃÑо¿ÀûÓÃģʽÉúÎï»ùÒò×éÐòÁУ¬Õë¶ÔPIP2-Moesinͨ·ºÍFcÊÜÌåͨ·µÄ¼¸ÖֹؼüÐźŵ°°×½øÐÐÁËϵͳ·¢Éúѧ·ÖÎö¡£½á¹ûÌáʾ£¬ÕâÖÖ»ùÓÚPIP2ºÍMoesinµ°°×µÄÐźŴ«µÝͨ·µÄ³öÏÖ£¬Ô¶ÔçÓÚÏÖ´úÃâÒßϵͳÖеÄFcÊÜÌå¼Ò×壻ËüÃÇ¿ÉÄÜÔÚFcÊÜÌå³öÏÖ֮ǰ£¬¾ÍÒѾÓëSykµÈÏÂÓÎÐźÅÐγÉÐͬ¹ØÏµ£¬¹²Í¬½éµ¼ÔʼµÄÍÌÊÉ×÷Óá£ÀýÈ磬Syk/Zap70ºÍmoesinÐźſÉÒÔ×·Ëݵ½8ÒÚÄêǰ£¬PI3KµÄǰÉí¿ÉÒÔ»ØËÝÔ¼13ÒÚÄê¡£×÷ÕßÒò´ËÌá³öÒ»¸ö¼ÙÉ裺ÎÒÃÇÏÖ´úÒâÒåÖеĿÉÒÔÀûÓÃimmune tyrosineµÄÃâÒßÊÜÌåµÄ³öÏÖ£¬±ÈÈçFcR£¬ÐèÒªÁ½¸öǰÌᣬһ¸öÊÇRAGת×ù×ÓÈëÇÖ(Rag transposon invasion)£¬ÁíÒ»¸öÊÇÁ½´ÎÈ«»ùÒò×鏴֯£¨Whole genome duplication, or polyploidy£©¡£ÎÒÃǵÄFcRÒò´ËÔÚ9ǧÍòÄêǰ³öÏÖ£¬ºÍ»ñµÃÐÔÃâÒßÒ»Æð½øÈëÁËĿǰµÄ¸ßËÙÑÝ»¯×´Ì¬¡£¶øÕâÁ½¸öǰÌáʼþµÄ·¢Éú¶¼ÒªÍíÓÚmoesinºÍSykµÈ·Ö×Ó¡£Õâ»ù±¾ËµÃ÷£¬ÎÒÃÇÏÖÔڹ۲쵽µÄimmune tyrosineÐźŲ¢²»ÊÇÃâÒßÊÜÌå×Ô¼º´øÀ´µÄ£¬¶øÊÇ»ñµÃÐÔÃâÒßϵͳ½Ù³ÖÁËÔ¶¹ÅµÄÒÔĤ¸ÐӦΪ»ù´¡µÄÍÌÊɹ¦ÄÜ¡£ÒòΪRagµÄediting¹¦ÄÜ£¬MHCµÄÑ¡ÔñѹÁ¦µÈÔÒò£¬Õâ¸öÐÂϵͳµÃÒÔÔÚ¼¸Ç§ÍòÄêÄÚ½ø»¯µØìÅÈ»¶áÄ¿£¬²¢³ÉΪÎÒÃÇÑо¿µÄÖØµã¡£¶øÎÒÃÇÒ»Ö±ÒÀÀµµÄÖ¬·¾ÖØ×éÓÕ·¢µÄÍÌÊɹ¦ÄÜÒ²Ò»Ö±»¹ÔÚ±»ÏÖ´úµÄÍÌÊÉϸ°ûËù´«³Ð¡£ÔÚ¹ÌÌå¿ÅÁ£¸ÐÓ¦£¬µ÷Àí×÷ÓÃȱ·¦µÄÇé¿öϼÌÐøÖ´ÐÐ×î¹ÅÀϵÄcellular immunity¡£¸ÃÑо¿¶ÔÎÒÃÇÈÏÖªÃâÒß¼¤»î£¬ÃâÒßÊÜÌåºÍϸ°ûÐÎ̬£¬Á×Ö¬´úл·Ö²¼ºÍÐÅºÅÆðÔ´¹ØÏµµÈ¶¼¾ßÓÐÆô·¢ºÍ½è¼øÒâÒå¡£

ͼ2. »ùÓÚPIP2Óë»ùÓÚÏÖ´úÃâÒßÊÜÌåµÄÖ÷ÒªÐźŵ°°×µÄÆðԴ˳Ðò
ʯÑå½ÌÊÚºÍÏÄÌú¸±Ñо¿Ô±Îª¸ÃÏîÑо¿µÄ¹²Í¬Í¨Ñ¶×÷Õß¡£Ç廪´óѧÉúÃü¿ÆÑ§ÔºÒѱÏÒµPTNÏîÄ¿²©Ê¿ÉúÄÂÀö±ùºÍ¼ÓÄô󿨶û¼ÓÀï´óѧÒѱÏÒµ²©Ê¿ÉúÍ¿ÖÐÔΪ±¾ÎĵĹ²Í¬µÚÒ»×÷Õߣ¬±±¾©´óѧ»ùÒò×é¶àÑùÐÔÓëÑÝ»¯ÊµÑéÊÒÃçÁÖ²©Ê¿Îª¸Ã¿ÎÌâ×ö³öÖØÒª¹±Ïס£Ñо¿µÄ¿ªÕ¹Í¬Ê±»¹µÃµ½ÁËÇ廪´óѧÉúÃü¿ÆÑ§Ôº¶ÅÑÇ骿ÎÌâ×éÒÔ¼°Öйú¿ÆÑ§Ôº¹ý³Ì¹¤³ÌÑо¿ËùÂí¹â»Ô¿ÎÌâ×éµÄ´óÁ¦Ö§³Ö¡£¸ÃÑо¿µÃµ½¹ú¼Ò×ÔÈ»¿ÆÑ§»ù½ðί¡¢Ç廪´óѧÃâÒßѧÑо¿Ëù¼°Ç廪´óѧ-±±¾©´óѧÉúÃü¿ÆÑ§ÁªºÏÖÐÐĵľ·Ñ×ÊÖú¡£
¡òÂÛÎÄÁ´½Ó£ºhttps://www.nature.com/articles/s41467-018-06744-7