1xbetÍøÒ³°æ

1xbetÍøÒ³°æ - Ëѹ·Ö¸ÄÏ

1xbetÍøÒ³°æ: ×îгɹû

1xbetÍøÒ³°æ:1xbetÍøÒ³°æ¼Öâù²ý¿ÎÌâ×é½ÒʾСÊó·¢ÉùµÄ·Ö×Ó»ù´¡

2023-02-20

ÉùÒô¿ÉÒÔ´«µÝÖØÒªµÄÐÅÏ¢°üÀ¨¸öÌåÉ罻״̬¡¢Î»ÖÃÒÔ¼°¾­ÑéµÈ£¬ÊÇÄñÀ࣬Äö³ÝÀදÎ·ÇÈËÁ鳤ÒÔ¼°ÈËÀàµÈÎïÖÖÖÖÄÚ½»Á÷µÄÖØÒªÃ½½é¡£Ñо¿·¢ÉùµÄ·Ö×Ó»úÖÆÓÐÖúÓÚ¸üºÃµÄÀí½âÈËÀàÓïÑԵIJúÉúºÍÑÝ»¯µÄ»úÖÆ£¬Í¬Ê±¶ÔÀí½âÓïÑÔ¹¦ÄÜÎÉÂÒ£¬×Ô±ÕÖ¢µÈÏà¹Ø¼²²¡µÄ·¢²¡»úÖÆ¾ßÓÐÖØÒªµÄÒâÒå¡£

2023Äê02ÔÂ13ÈÕ£¬1xbetÍøÒ³°æ¡¢Ç廪-IDG/Âó¸êÎÄÄÔ¿ÆÑ§Ñо¿Ôº¡¢Ç廪-±±´óÉúÃü¿ÆÑ§ÁªºÏÖÐÐÄ¡¢Ç廪´óѧÄÔÓëÖÇÄÜʵÑéÊÒ¼Öâù²ý¿ÎÌâ×éÔÚ¾«Éñ¼²²¡ÁìÓòȨÍþѧÊõÆÚ¿¯¡¶·Ö×Ó¾«Éñ²¡Ñ§¡·(Molecular Psychiatry)ÔÚÏß·¢±íÁËÌâΪ¡°×ªÂ¼Òò×ÓTCF7L2×÷Ϊһ¸ö·Ö×Ó¿ª¹ØÍ¨¹ýDNA½áºÏ½á¹¹ÓòÔÚÖÐÄÔ¿ØÖƲ¸È鶯Îï·¢Éù¡±(TCF7L2 acts as a molecular switch in midbrain to control mammal vocalization through its DNA binding domain but not transcription activation domain)µÄÑо¿ÂÛÎÄ£¬½ÒʾÁËСÊó·¢ÉùµÄ·Ö×Ó»ù´¡¡£

ÉùÒôµÄ²úÉúÐèÒªÇûÌå¶à¸ö²¿·ÖÏ໥Эͬ×÷Óã¬Èçºí²¿¼¡È⣬ºôÎüÒÔ¼°ºá¿çǰÄÔµ½ÄԸɵÄÉñ¾­ÍøÂçµÈ¡£ÖÐÄÔµ¼Ë®¹ÜÖÜΧ»ÒÖÊ(Periaqueductal gray, PAG)ÊÇ´óÄÔÖÐÒ»¸ö±È½Ï±£ÊصĽṹ£¬ÔÚСÊó£¬Ã¨ÒÔ¼°·ÇÈËÁ鳤ÀදÎïÖб»ÈÏΪÊÇ¿ØÖÆÏÈÌìÐÔ·¢ÉùµÄÒ»¸öÖØÒª½Úµã¡£Òò´Ë£¬Ðí¶à¶Ô·¢ÉùµÄÑо¿Î§ÈÆÔÚÒÔPAGΪÖÐÐĵÄÉÏÏÂÓεÄÉñ¾­»·Â·ÉÏ£¬È»¶ø£¬¶ÔÓÚPAG¿ØÖÆ·¢ÉùµÄ·Ö×Óµ÷¿Ø»úÖÆÈ´ÏÊΪÈËÖª¡£

ͼ1. TCF7L2 Y337HµãÍ»±äËðº¦Ð¡Êó·¢Éù

¸ÃÑо¿£¬Ê×ÏÈͨ¹ý»¯Ñ§ÓÕ±ä¼ÁN-ÒÒ»ù-N-ÑÇÏõ»ùëå(N-ethyl-N-nitrosourea, ENU)¶ÔСÊó»ùÒò½øÐÐÓձ䣬Ȼºó¶Ô·¢ÉùȱÏݵÄСÊó½øÐÐɸÑ¡£¬·¢ÏÖTcf7l2»ùÒò¶Ôµ÷¿ØÐ¡Êó·¢ÉùÆðµ½¹Ø¼ü×÷Ó㬲¢ÇÒÓ°ÏìÁËСÊó·¢ÉùµÄÒô½ÚµÄ¸´ÔÓÐÔ(ͼ1); ÄÔÇøÒÔ¼°Ï¸°ûÌØÒìµÄÇóýTcf7l2Ëðº¦ÁËСÊóµÄ·¢Éù£¬ËµÃ÷Tcf7l2ÔÚPAGÄÔÇøÐË·ÜÐÔÉñ¾­ÔªµÄÕý³£±í´ï¶ÔСÊó·¢ÉùÖÁ¹ØÖØÒª£»Nanopore²âÐò·¢ÏÖÁËTcf7l2µÄÐí¶àеÄת¼±¾£¬ÌØÒìµÄÇóýTcf7l2»ùÒò¶ÌµÄת¼±¾Í¬ÑùËðº¦Ð¡Êó·¢Éù²¢ÇÒͨ¹ý˫ӫ¹âËØÃ¸±¨¸æÏµÍ³·¢ÏÖTcf7l2»ùÒòµÄÍ»±ä½â³ýÁ˶̵Äת¼±¾¶Ôת¼µÄÒÖÖÆ£¬°µÊ¾×ÅTCF7L2¿ÉÄÜͨ¹ýת¼ÒÖÖÆµ÷¿ØÐ¡Êó·¢Éù£»×îºó£¬Ñо¿Õß½«×Ô±ÕÖ¢»¼ÕßTcf7l2»ùÒòµÄµãÍ»±äÒýÈ뵽СÊóÉÏ£¬Í¬ÑùÔì³ÉСÊó·¢ÉùȱÏÝ¡£

×ÛÉÏ£¬¸ÃÑо¿´Ó·Ö×ÓÒÅ´«Ñ§½Ç¶È£¬Ñо¿ÁËTcf7l2µ÷¿ØÐ¡Êó·¢ÉùµÄ»úÖÆ£¬¸ÃÑо¿ÓÐÖúÓÚ¿ÆÑ§¼ÒÃÇÉîÈëÀí½âTcf7l2ÔÚÉñ¾­ÏµÍ³ÖеÄй¦ÄÜ£¬ÎªÀí½âÈËÀàÓïÑÔºÍÆäÏà¹Ø¼²²¡µÄ·¢Éù»úÖÆÌṩÁË·Ö×ÓÒÅ´«µÄÀíÂÛ»ù´¡¡£

ͼ2. Tcf7l2µ÷¿ØÐ¡Êó·¢ÉùµÄģʽͼ

1xbetÍøÒ³°æ¼Öâù²ý½ÌÊÚΪ±¾ÎĵÄͨѶ×÷Õߣ¬1xbetÍøÒ³°æ²©Ê¿ÉúÆë»Ô»ÔΪ±¾ÎĵÚÒ»×÷Õߣ¬Ç廪´óѧÄÔÓëÖÇÄÜʵÑéÊÒÂÞÀòÀÏʦ£¬Ç廪´óѧ²©Ê¿Éú¬²Ê¾°¡¢³ÂÈóÔóÒÔ¼°ºÍ±±¾©Ê¦·¶´óѧÕÂÏþ»ÔÍŶÓΪ±¾ÎÄ×ö³öÁËÖØÒªµÄ¹±Ïס£¸ÃÑо¿¹¤×÷µÃµ½¹ú¼Ò×ÔÈ»¿ÆÑ§»ù½ð£¬Ç廪-±±´óÉúÃü¿ÆÑ§ÁªºÏÖÐÐÄ£¬Ç廪-IDG/Âó¸êÎÄÄÔ¿ÆÑ§Ñо¿ÔºµÄÖ§³Ö¡£

ÎÄÏ×Á´½Ó£ºhttps://www.nature.com/articles/s41380-023-01993-5

ɨÃè¶þάÂëÖ±´ïÔ­ÎÄÁ´½Ó

ÉÏÒ»Ìõ£ºÕÅÁÖçù/ÕÅÕþ/ÍõÐÂȪ/Justin Jang Hann ChuºÏ×÷½âÎöйÚԭʼÖ겡¶¾¸ÐȾÓÕµ¼¹ãÆ×ÖкͿ¹ÌåµÄ·Ö×Ó»úÖÆ

ÏÂÒ»Ìõ£º1xbetÍøÒ³°æÕÅÁÖçù¡¢ÉúÃüѧԺÍõÐÂȪÍŶӷ¢ÏÖ¹ãÆ×¸ßЧйڲ¡¶¾ÄÉÃ׿¹Ìå

ÄúÏÖÔÚµÄλÖ㺠Ê×Ò³ > ½ñÈÕҽѧ > ×îгɹû > ÕýÎÄ
1xbetÍøÒ³°æ - Ëѹ·Ö¸ÄÏ